Elevated Kappa Light Chain Ratio

Lambda light chain concentration range.

Elevated kappa light chain ratio.

Abnormal free light chain production has also been reported to be prognostic of a worse outcome in multiple myeloma and chronic lymphocytic leukaemia. The exact normal ratio of kappa to lambda according to a novel polyclonal free light chain assay ranges from 0 26 to 1 65. Told me my kappa light chain is elevated at 26. 5 7 26 3 mg ml.

The ratio or proportion between the kappa and lambda light chains indicates an excess production of one chain over the other and therefore can be used as an indication of disease progression or remission said dr. It is normal for there to be small fluctuations in the uninvolved light chain concentration over time which have no clinical significance at all. She told me not to worry and we ll check again in 3 months. What else should i ask answered by dr.

Authors aneta niewmierzycka. Epub 2015 jun 3. An abnormal light chain ratio has been defined as a kappa to lambda chain ratio of less than 0 26 or more than 1 65. Lambda and kappa light chains.

In the context of mgus or myeloma significantly increased free light chain production and a markedly abnormal kappa lambda ratio indicate an increased risk of disease progression. Kappa light chain concentration range. These unlinked chains are known as free light chains. This balance of kappa and lambda together is called the kappa lambda ratio which can also indicate a change in levels of disease.

Increased lambda free light chains and a decreased kappa lambda ratio may be seen with plasma cell disorders that produce excess monoclonal lambda light chains. There are two types of light chains. You have a minimal degree of change this may be wi. A free light chains test measures the amount of lambda and kappa free light chains in the blood.

In a healthy individual the total kappa to lambda ratio is roughly 2 1 in serum measuring intact whole antibodies or 1 1 5 if measuring free light chains with a highly divergent ratio indicative of neoplasm. Normal values for kappa lambda and flc ratio.